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KMID : 0359819730020020015
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Journal of Korean Neurosurgical Society
1973 Volume.2 No. 2 p.15 ~ p.21
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A Study of Experimental Spinal Cord Injury in the Cat
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Abstract
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Local spinal cord cooling and glucocorticoid administration have been shown to diminish the degree of traumatic hemorrhagic necrosis and improve´ spinal cord function after impact injury. Local cooling is said to influence multiple neural enzymatic iirodesses diminish the cellular metabolic rate and lessen the oxygen requirements.
Steroid is known to maintain vascular integrity after injury and protect cellular membrane in the state of poor perfusion.
As a preliminary report, this experimental study demonstrates the sequence of pathologic changes occurring from hours to days after the spinal cord of a cat had been impacted by a 400 gm-cm force respectively and, thereafter evaluated the effect of local cooling and steroid administration on the functional recovery of the spinal cord. Spinal injuries was produced by dropping a 20gm weight 20 cm height through a vented guide tube to strike the exposed dura and cord.
Animals were sacrificed hours or days after injury. The thoracic cord was removed to include the injured tissue adjacent cord for control.
The specimens were taken for histological study and this was correlated with the clinical observation by Tarlov s classification.
In the acute group (From l hour to 8 hours after injury), multiple hemorrhages and necrosis occurred in the central gray matter and periaxonal swelling in the white matter adjacent to gray matter.
At 15 days all most gray matter was replaced by a large central cavity in which numerous lipidphagocytes were accumulated and disruption of white matter was severe in the adjacent to the cavity.
The motor neurons were shown complete central chromatolysis in the all groups.
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